"It took geneticist Craig Venter 15 years and US$40 million to synthesize the genome of a bacterial parasite. Today, an academic team made up mostly of undergraduate students reports the next leap in synthetic life: the redesign and production of a fully functional chromosome from the baker’s yeast Saccharomyces cerevisiae.
As a eukaryote, a category that includes humans and other animals, S. cerevisiae has a more complex genome than Venter's parasite. "
“I wasn’t sceptical about whether it could be done,” Boeke says. The question, he explains, was: “How can we make this different from a normal chromosome and put something into it that’s really going to make it worthwhile?”
Nature - First synthetic yeast chromosome revealed
BBC - Scientists hail synthetic chromosome advance
Wiki - Yeast artificial chromosome